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Cat. No. | Product Name | ||
---|---|---|---|
L2200 | 酪氨酸激酶分子库 | 1016 compounds | |
1016 种酪氨酸激酶抑制剂的独特集合,可用于高通量筛选和高内涵筛选; | |||
L1300 | PI3K/Akt/mTOR 化合物库 | 420 compounds | |
420 种与PI3K/Akt/mTOR 相关的生物活性小分子化合物的特有集合,用于PI3K/Akt/mTOR 相关研究以及高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TQ0141 |
Taltobulin
HTI-286,SPA-110 |
Apoptosis; Microtubule Associated | Apoptosis; Cytoskeletal Signaling |
Taltobulin (HTI-286) 是一种三肽半胱氨酸的合成类似物,是一种微管蛋白抑制剂,在体外抑制肝肿瘤细胞增殖和体内肿瘤生长。Taltobulin 具有细胞毒性,诱导有丝分裂停滞以及凋亡 (apoptosis),可用于研究乳腺癌和与微管组织相关的疾病。 | |||
T3623 |
Cobimetinib
可美替尼,考比替尼,RG7420,XL518,GDC-0973 |
Apoptosis; MEK | Apoptosis; MAPK |
Cobimetinib (GDC-0973) 是一种可口服的 MEK1选择性抑制剂,抑制MEK1的IC50为4.2 nM。 | |||
T10406 |
Tuvusertib
M1774,ATR inhibitor 1 |
Apoptosis; ATM/ATR; Others; Chk | Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others; PI3K/Akt/mTOR signaling |
Tuvusertib (M1774) 是一种可口服的共济失调毛细血管扩张和 Rad3相关(ATR)激酶抑制剂(Ki< 1 µΜ),具有选择性和潜在的抗肿瘤活性。Tuvusertib 选择性抑制 ATR 活性,阻断丝氨酸/苏氨酸蛋白激酶检查点激酶1 (CHK1)的下游磷酸化,从而抑制 DNA 损伤检查点激活,破坏 DNA 损伤修复,诱导肿瘤细胞凋亡。 | |||
T9533 |
BC-LI-0186
4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide |
Others | Others |
BC-LI-0186 (4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide) 是选择性抑制亮氨酸 tRNA 合成酶与 Ras 相关的 GTP 结合蛋白 D 相互作用(IC50=46.11 nM)。BC-LI-0186能有效抑制肿瘤相关 MTOR 突变体的特性和雷帕霉素耐药癌细胞的生长,能够用于肺癌的相关研究。 | |||
T26981 |
Ceralasertib formate
Ceralasertib,AZD-6738,AZD 6738,AZD6738 |
||
Ceralasertib is an orally available inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase. Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR- |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3314 |
Perillyl alcohol
Isocarveol,Perilla alcohol,紫苏醇 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Perillyl alcohol (Isocarveol) 是一种单萜,可在不影响正常细胞的情况下诱导肿瘤细胞凋亡。 | |||
TN1410 |
Asperulosidic acid
ASPA,车叶草苷酸 |
ERK; NF-κB | MAPK; NF-κB |
Asperulosidic acid (ASPA) 是从白花蛇舌草药中提取的一种环烯醚萜苷,具有抗肿瘤、抗氧化和抗炎作用。它通过抑制 NF-κB 和丝裂原活化蛋白激酶信号通路抑制炎性细胞因子释放发挥抗炎作用。 | |||
T6S1315 |
Oroxylin A
千层纸素A,6-Methoxybaicalein,Baicalein 6-methyl ether |
Virus Protease; HIF/HIF Prolyl-Hydroxylase; Autophagy | Autophagy; Chromatin/Epigenetic; Metabolism; Microbiology/Virology |
Oroxylin A (Baicalein 6-methyl ether) 是一种有活性的黄酮,具有较强的抗癌作用。 | |||
T81484 |
Phorbol 12-tiglate
|
||
Phorbol12-tiglate为Phorbol衍生物,后者乃巴豆油水解产物,可激活蛋白激酶C,进而促进肿瘤发展。Phorbol及其衍生物在生物医学领域,广泛用于建立致癌模型研究。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00564 |
PLXDC2 Protein, Mouse, Recombinant (His)
Tumor endothelial marker 7-related pro... |
Mouse | HEK293 Cells |
Mouse Plexin domain-containing protein 2(PLXDC2) is a single-pass type I membrane protein. The protein is expressed in tumor endothelium and in vessels of some normal tissues, such as the muscle and lung. PLXDC2 can interact with CTTN, and may play a role in tumor angiogenesis. | |||
TMPH-02599 |
C1QTNF6 Protein, Mouse, Recombinant (His & SUMO)
Complement C1q tumor necrosis factor-related |
Mouse | E. coli |
C1QTNF6 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-02600 |
C1QL3 Protein, Mouse, Recombinant (His & Myc)
C1ql,Gliacolin,C1q and tumor necrosis factor-re... |
Mouse | Baculovirus Insect Cells |
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC1 and PCK1 and hence decreases de novo glucose production. | |||
TMPH-02555 |
C1QL1 Protein, Mouse, Recombinant (His)
C1q and tumor necrosis factor-related ... |
Mouse | P. pastoris (Yeast) |
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses. | |||
TMPJ-01304 |
C1QTNF1 Protein, Human, Recombinant (His)
C1QTNF1,G Protein-Coupled Receptor-Interacting ... |
Human | HEK293 Cells |
C1QTNF1 is a secreted protein,contains 1 C1q domain and 1 collagen-like domain. C1qTNF proteins constitute a highly conserved family of Acrp30/Adiponectin paralogs that share a modular organization comprising an N-terminal signal peptide, a short variable region, a collagenous domain and a C-terminal globular domain. C1qTNF proteins are predicted to have trimeric structures that assemble into hexameric and higher order molecular forms. C1QTNF1 is a novel adipokine, providing a significant framew... | |||
TMPJ-00981 |
PTX3 Protein, Mouse, Recombinant (His)
alpha-induced protein 5,pentraxin 3, long,pentaxin-... |
Mouse | HEK293 Cells |
Pentraxin-related protein PTX3, also known as Tumor necrosis factor-inducible gene 14 protein (TSG-14), belongs to the pentraxin family. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. It’s subunit is a disulfide-linked homooctamer that binds to C1q. PTX3 concentration is elevated in the joint fluid of patients with rheumatoid arthritis (RA), indicating that PTX3 may be a potential mediator... | |||
TMPH-01129 |
C1QTNF3 Protein, Human, Recombinant (His)
C1QTNF3,CORS26,Collagenous repeat-containing sequence 26 kDa... |
Human | E. coli |
C1QTNF3 Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPJ-00110 |
GITR/TNFRSF18 Protein, Mouse, Recombinant (hFc & His)
Tnfrsf18,GITR-D,CD357,AITR,Tumor necrosis factor re... |
Mouse | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 18(Gitr) contains 3 TNFR-Cys repeats and it have four isforms.IsformA、isformB and isformC is single-pass type I membrane protein and isformD is a secreted protein. The protein is the receptor for TNFSF18.It seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. It mediated NF-kappa-B activation via the TRAF2/NIK pathway.It binds to TRAF1, TRAF2, and... | |||
TMPH-01130 |
C1QTNF3 Protein, Human, Recombinant (His & Myc)
Secretory protein CORS26,Collagenous repeat-contain... |
Human | Baculovirus Insect Cells |
C1QTNF3 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus. | |||
TMPH-02598 |
C1QTNF3 Protein, Mouse, Recombinant (His)
Secretory protein CORS26,C1QTNF3,Complement C1q |
Mouse | HEK293 Cells |
C1QTNF3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-10xHis tag. The predicted molecular weight is 26.6 kDa and the accession number is Q9ES30. | |||
TMPJ-01372 |
Cornulin Protein, Human, Recombinant (His)
Tumor-Related Protein,58 kDa Heat... |
Human | E. coli |
Cornulin is a member of the fused gene family of molecular chaperones. Human Cornulin contains N-terminus EF-hand domains and Ca2+ binding domains, and two glutamine- and threonine-rich 60 amino acid repeats in its C-terminus. Cornulin involves in the mucosal/epithelial immune response and epidermal differentiation. Cornulin is a survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and ... | |||
TMPH-02497 |
Adipolin Protein, Mouse, Recombinant (His)
Adipose-derived insulin-sensitizing factor,Complement C1q |
Mouse | Baculovirus Insect Cells |
Adipolin Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 33.9 kDa and the accession number is Q8R2Z0. | |||
TMPH-02496 |
Adipolin Protein, Mouse, Recombinant (E. coli, His)
C1qtnf12,Ctrp12,Complement C1q tumor necrosis facto... |
Mouse | E. coli |
Adipolin Protein, Mouse, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.0 kDa and the accession number is Q8R2Z0. | |||
TMPJ-00546 |
EFNA1 Protein, Human, Recombinant (hFc)
TNFAIP4,LERK1,Tumor Necrosis Factor α-Induced P... |
Human | HEK293 Cells |
Ephrin-A1 is a member of the A-type ephrin family of cell surface proteins that function as ligands for the A-type Eph receptor tyrosine kinase family. Ephrin-A1 can be induced by TNF and IL1B. Its expression levels can be down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells. Soluble Ephrin-A1 is necessary for the transformation of HeLa and SK-BR3 cells and participates in the... | |||
TMPJ-00274 |
LTBR Protein, Human, Recombinant (His)
TNFCR,Tumor Necrosis Factor Receptor Superfamily Me... |
Human | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 3, also known as Lymphotoxin-beta receptor,Tumor necrosis factor C receptor,Tumor necrosis factor receptor 2-related protein,Tumor necrosis factor receptor type III,LTBR,TNFCR, TNFR3 and TNFRSF3, is a member of the tumor necrosis factor (TNF) family of receptors. LTBR is a single-pass type I membrane protein and contains four TNFR-Cys repeats. It is expressed on the surface of most cell types, but not on T and B lymphocytes. LTBR and its ligand p... | |||
TMPJ-00152 |
CD40 Ligand Protein, Human, Recombinant (His & Avi), Biotinylated
CD40 Ligand,TNF-Related Activation Protein... |
Human | HEK293 Cells |
CD40 Ligand Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with N-6xHis-Avi tag. The predicted molecular weight is 23-28 KDa and the accession number is P29965. | |||
TMPJ-00150 |
CD40 Ligand Protein, Human, Recombinant (Mammalian)
CD40LG,Tumor Necrosis Factor Ligand Superfamily Mem... |
Human | HEK293 Cells |
CD40 Ligand Protein, Human, Recombinant (Mammalian) is expressed in HEK293 mammalian cells. The predicted molecular weight is 16-18 KDa and the accession number is P29965. | |||
TMPJ-00151 |
CD40 Ligand Protein, Human, Recombinant
CD40LG,CD40 Ligand,TRAP,TNF-Related Activation ... |
Human | E. coli |
CD40 Ligand Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 KDa and the accession number is P29965. | |||
TMPJ-00153 |
CD40 Ligand Protein, Human, Recombinant (His & Flag)
CD40LG,Tumor Necrosis Factor Ligand Superfamily Mem... |
Human | HEK293 Cells |
CD40 Ligand Protein, Human, Recombinant (His & Flag) is expressed in HEK293 mammalian cells with N-6xHis-Flag tag. The predicted molecular weight is 19-24 KDa and the accession number is P29965. | |||
TMPY-02869 |
MMP-12 Protein, Human, Recombinant (catalytic domain)
HME,ME,MMP-12,MME,matrix metallopeptidase 12 |
Human | E. coli |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, ... | |||
TMPY-04396 |
C-ABL/ABL1 Protein, Human, Recombinant (GST)
v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine k... |
Human | Baculovirus Insect Cells |
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an... | |||
TMPH-01048 |
CEACAM5 Protein, Human, Recombinant (E398K, His)
Carcinoembryonic antigen-related cell adhesion mole... |
Human | HEK293 Cells |
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression. Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6. Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells.; (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. CEACAM5... | |||
TMPK-00134 |
ULBP-1 Protein, Human, Recombinant (His & Avi)
ALCAN-beta,ALCAN-β,ULBP-1,MULT-1,NKG2D ligand 1,AET1I,NKG2DL... |
Human | HEK293 Cells |
Cell surface proteins major histocompatibility complex (MHC) class I-related chain A (MICA) and UL16-binding proteins (ULBP) 1, 2, and 3 are up-regulated upon infection or tumor transformation and can activate human natural killer (NK) cells. ULBP-1 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.2 kDa and the accession number is Q9BZM6. | |||
TMPK-00135 |
ULBP-1 Protein, Human, Recombinant (His & Avi), Biotinylated
ALCAN-β,NKG2D ligand 1,ULBP-1,NKG2DL,MULT-1,ULBP1,ALCAN-beta... |
Human | HEK293 Cells |
Cell surface proteins major histocompatibility complex (MHC) class I-related chain A (MICA) and UL16-binding proteins (ULBP) 1, 2, and 3 are up-regulated upon infection or tumor transformation and can activate human natural killer (NK) cells. ULBP-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 25.2 kDa and the accession number is Q9BZM6. | |||
TMPK-00249 |
TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi), Biotinylated
TNFRSF10D,CD264,TRUNDD,DCR2,RSF10D,TRAILR4 |
Human | HEK293 Cells |
TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL-R2/DR5 as well as TRAIL-R3/DcR1 and TRAIL-R4/DcR2 were significantly higher expressed in advanced tumour stages. TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is ... | |||
TMPK-00248 |
TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi)
DCR2,TNFRSF10D,RSF10D,CD264,TRUNDD,TRAILR4 |
Human | HEK293 Cells |
TNF-related apoptosis inducing ligand (TRAIL) is a potential antitumor protein known for its ability to selectively eliminate various types of tumor cells without exerting toxic effects in normal cells and tissues. TRAIL-R2/DR5 as well as TRAIL-R3/DcR1 and TRAIL-R4/DcR2 were significantly higher expressed in advanced tumour stages. TRAIL R4/TNFRSF10D Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 19.4 kDa and t... | |||
TMPJ-00999 |
UBE2D1 Protein, Human, Recombinant (GST)
Ubiquitin-conjugating enzyme E2(17)KB 1,UB,UbcH5,UBC5A,Stimu... |
Human | E. coli |
Ubiquitin-conjugating enzyme E2 D1(UBE2D1)belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transc... | |||
TMPJ-01412 |
LRP-12 Protein, Human, Recombinant (His)
LRP-12,ST7,Suppressor of Tumorigenicity 7 Prote... |
Human | HEK293 Cells |
Low-Density Lipoprotein Receptor-Related Protein 12 (LRP12) belongs to the LDLR family. LRP12 is a type I transmembrane protein annd widely expressed in heart, skeletal muscle, brain, lung, placenta and pancreas. LRP12 contains 2 CUB domain and 5 LDL-receptor class A domain. LRP12 has been shown to interact with GNB2L1, ZFYVE9 and ITGB1BP3. LRP12 is a receptor probably, which may be involved in the internalization of lipophilic molecules and/or signal transduction. In addition, LRP12 may act as ... | |||
TMPY-01416 |
OLFM4 Protein, Human, Recombinant (His)
hGC-1,GC1,OLM4,bA209J19.1,GW112,olfactomedin 4,OlfD,hOLfD,UN... |
Human | HEK293 Cells |
Olfactomedin-4, also known as G-CSF-stimulated clone 1 protein, Antiapoptotic protein GW112, and OLFM4, is a secreted protein that contains one olfactomedin-like domain. The OLFM4 gene was recently reported to inhibit various apoptotic pathways and promote the proliferation of cancer cells, suggesting that OLFM4 might serve as a diagnostic marker for human cancers. Thus, OLFM4 mRNA might be a useful tool to support the diagnosis of cancer, irrespective of the clinical stages. It is overexpressed... | |||
TMPY-02572 |
TXNDC17 Protein, Human, Recombinant
thioredoxin domain containing 17,TXNL5,TRP14 |
Human | E. coli |
Thioredoxin-related protein of 14 kDa (TRP14, also called TXNDC17 for thioredoxin domain containing 17, or TXNL5 for thioredoxin-like 5) is an evolutionarily well-conserved member of the thioredoxin (Trx)-fold protein family that lacks activity with classical Trx1 substrates. TXNDC17 is a novel 14-kDa disulfide reductase of the TXN (thioredoxin) family. TXNDC17 is involved in the TNF (tumor necrosis factor) signaling pathway. Moreover, TXNDC17 plays an important role in Taxol resistance via enha... | |||
TMPJ-00680 |
ANGPTL7 Protein, Human, Recombinant (His)
CDT6,Cornea-derived transcript 6 protein,Angiopoiet... |
Human | HEK293 Cells |
Angiopoietin-like 7 (ANGPTL7) is a secreted glycoprotein that is structurally related to the angiopoietins. Members of this protein family contain an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL7 shares 89% aa sequence identity with mouse and rat ANGPTL7. It is secreted as a 45-50kDa monomer that forms disulfide-linked homotrimers and tetramers via the coiled coil domain. ANGPTL7 is expressed in the corneal stroma, trabecular meshwork, and sclera and is elevated ... | |||
TMPJ-00578 |
CEACAM21 Protein, Human, Recombinant (His)
Carcinoembryonic antigen-related cell adhesion mole... |
Human | HEK293 Cells |
Carcinoembryonic antigen-related cell adhesion molecule 21 is a protein that in humans is encoded by the CEACAM21 gene. It belongs to the immunoglobulin superfamily. CEA family.containing 1 Ig-like C2-type (immunoglobulin-like) domain.It was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been a... | |||
TMPY-02651 |
p63 Protein, Human, Recombinant (His & GST)
p40,TP53L,RHS,B(p51A),p51,KET,NBP,B(p51B),OFC8,tumor |
Human | Baculovirus Insect Cells |
Tumor protein p63 is a protein also known as transformation-related protein 63, TP63, and p63. Tumor protein p63 / p63 is a member of the p53 family of transcription factors whose members P53, p63, and p73 have similar features in their gene structures and functions. An animal model, p63-/- mice has been useful in difining the role p63 plays in the development and maintenance of stratified epithelial tissues. This p63 encoding protein p63 has a dramatic impact on replenishment of cutaneous epith... | |||
TMPY-01816 |
Pentraxin 3 Protein, Human, Recombinant (His)
TNFAIP5,pentraxin 3,PTX3,TSG-14 |
Human | HEK293 Cells |
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein that contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cycl... | |||
TMPY-04547 |
PBK/TOPK Protein, Human, Recombinant (His)
HEL164,Nori-3,CT84,TOPK,PDZ binding kinase,SPK |
Human | Baculovirus Insect Cells |
PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular fun... | |||
TMPY-04936 |
BCL2A1 Protein, Human, Recombinant (His)
BFL1,ACC1,ACC-2,GRS,ACC-1,HBPA1,BCL2 related pr... |
Human | E. coli |
B-cell lymphoma 2-related protein A1 (BCL2A1) is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs. Immunohistochemical expression of Wnt11 and BCL2A1 in complete moles and normal villi. Bcl2 family proteins control mitochondrial apoptosis and its members exert critical cell type and differentiation stage-specific functions, acting as barriers against autoimmunity or transformation. Anti-apoptotic Bcl2a1/Bfl1/A1 is frequently der... | |||
TMPY-02759 |
Kallikrein 6/KLK6 Protein, Human, Recombinant (His)
kallikrein-related peptidase 6,PRSS18,PRSS9,Klk7,Bs... |
Human | HEK293 Cells |
KLK6 (kallikrein-related peptidase 6), also known as Klk7, belongs to the peptidase S1 family, Kallikrein subfamily. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK6 is a serine protease that exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Klk7 sh... | |||
TMPY-02440 |
SAP/SH2D1A Protein, Human, Recombinant (His)
XLPD,EBVS,DSHP,SAP,MTCP1,IMD5,SH2 domain containing 1A,LYP,S... |
Human | E. coli |
SH2domain-containing protein 1A (SH2D1A / SAP) is a 128 amino acid protein, containing a single Src homology 2 (SH2) domain, flanked by 5 amino acids at the N-terminus and 25 amino acids at the C-terminus. The absence of a catalytic domain and the presence of an SH2domain suggest that SH2D1A regulates one or more signal transduction pathways. SH2D1A interacts with signaling lymphocytic activation molecule (SLAM), which is a transmembrane protein expressed on the surface of activated T and B cell... | |||
TMPY-02084 |
Thioredoxin 2/TRX2 Protein, Human, Recombinant (His)
MT-TRX,RP5-1119A7. 13-005,TRX2,MTRX,thioredoxin 2 |
Human | E. coli |
Thioredoxin-2, also known as TXN2, MTRX and TRX2, is a member of the thioredoxin family. Tryparedoxins (TXN) are thioredoxin-related proteins which, as trypanothione:peroxiredoxin oxidoreductases, constitute the trypanothione-dependent antioxidant defense and may also serve as substrates for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 / TXN2 contains one thioredoxin domain. It is widely expressed in adult (at protein level) and fetal tissues. Human Thioredoxin-2 / TXN2 is a small ... | |||
TMPY-02712 |
Serpin B3 Protein, Human, Recombinant (His)
T4-A,HsT1196,serpin peptidase inhibitor, clade B (ovalbumin)... |
Human | Baculovirus Insect Cells |
SERPINB3, also known as SCCA-1, belongs to the serpin family. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases. SERPINB3 is expressed in some hepatocellular carcinoma (at protein level). Its expression is closely related to cellular differentiation in both normal and malignant squamous cells. It seems to also be... | |||
TMPY-01771 |
Latexin Protein, Mouse, Recombinant (His)
latexin |
Mouse | E. coli |
Latexin, also known as endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor, TCI, ECI, and LXN, is a cytoplasm protein that belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in the heart, prostate, ovary, kidney, pancreas, and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional spe... | |||
TMPY-01204 |
SMYD2 Protein, Human, Recombinant (His)
ZMYND14,SET and MYND domain containing 2,HSKM-B,KMT3C |
Human | Baculovirus Insect Cells |
SET and MYND domain-containing protein 2, also known as HSKM-B, SMYD2, and KMT3C, is a member of the SMYD protein family. It contains one MYND-type zinc finger and one SET domain. Not much is known about SMYD2. However, the interest in better understanding the roles of SMYD2 has grown because of reports indicating that SMYD2 methylates p53 and histone H3. In Xenopus, SMYD1 and SMYD2 were expressed in various muscle tissues and related to muscle cell differentiation. SMYD2 mRNA is most highly exp... | |||
TMPY-02516 |
Interferon alpha 10/IFNA10 Protein, Human, Recombinant (hFc)
interferon, α10,interferon, alpha 10,IFN-alphaC,MGC119879,干扰... |
Human | HEK293 Cells |
Interferon alpha-10 (IFNA10) is a member of the interferon family. Interferons belong to the group of the regulatory glycoproteins, of low molecular mass. They are the products of infected cell-genome, but not virus, as a consequence of the cause answer by different inductors. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase. They allow communication between cells to trigger the protective defenses of the immune system that eradicate pathogen... | |||
TMPY-04260 |
p38 Protein, Human, Recombinant (His)
mitogen-activated protein kinase 14,CSPB1,PRKM14,RK... |
Human | Baculovirus Insect Cells |
MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK14 can be detected in the brain, heart, placenta, pancreas, and skeletal muscle and it is expressed to a lesser extent in the lung, liver, and kidney. MAPK14 is activated by various environmental stresses ... | |||
TMPY-00918 |
SFRP1 Protein, Human, Recombinant (His)
SARP2,secreted frizzled-related protein 1,... |
Human | HEK293 Cells |
Secreted frizzled-related protein 1, also known as sFRP1, is a 35 kDa prototypical member of the SFRP family. SFRP family consists of five secreted glycoproteins in humans acting as extracellular signaling ligands. Each is approximately 3 amino acids in length and contains a cysteine-rich domain (CRD) that shares 3-5% sequence homology with the CRD of Frizzled (Fz) receptors, a putative signal sequence, and a conserved hydrophilic carboxy-terminal domain. SFRPs act as soluble modulators of Wnt s... | |||
TMPY-00564 |
MCP-4 Protein, Human, Recombinant (His)
MCP-4,CCL13,SCYL1,NCC-1,MCP4,NCC1,CKb10,SCYA13,chemokine (C-... |
Human | P. pastoris (Yeast) |
Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family chemokine that is chemoattractant for eosinophils, basophils, monocytes, macrophages, immature dendritic cells, and T cells, and its capable of inducing crucial immuno-modulatory responses through its effects on epithelial, muscular and endothelial cells. Similar to other CC chem... |